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Clinically Studied NAD+ Technology

Measurable Advances
in NAD+ Science.

In the randomized, double-blind, placebo-controlled RENEWAL-NAD+ clinical trial, five days of oral LathMized® NAD+ supplementation produced a 53% higher intracellular whole-blood NAD measurement compared with placebo.

Shop the Protocol → Discover the Science
Result from the RENEWAL-NAD+ study using its specific formulation and dosing regimen; not established for other regimens.
Intracella LathMized NAD+ Products
Clinically Studied
53%
Higher whole-blood intracellular NAD vs. placebo
53%
Higher Intracellular Whole-Blood NAD
vs. placebo after five days using the studied regimen
100%
Participants Showing an Increase
All 23 evaluated treatment participants; 78.3% exceeded 30%
2×
NAD Metabolite Activity
Significant increases in MeNAM and 2PY metabolites
RCT
Randomized Human Trial
Peer-reviewed, published in GeroScience 2026
The Science

Clinically Demonstrated Increases in Intracellular Whole-Blood NAD

The RENEWAL-NAD+ study evaluated oral LathMized® NAD+ in healthy adults aged 45–75. Sixty participants were randomized, and 50 were included in the primary analysis.

The Result

After five days of supplementation using the study's dosing regimen, intracellular NAD measured in whole blood was 53% higher in the treatment group than in the placebo group (p = 5.48 × 10⁻¹⁴).

NAD measured in plasma did not significantly change.

Individual Responses

All 23 treatment participants evaluated for individual responses demonstrated an increase in intracellular whole-blood NAD from baseline. Eighteen participants (78.3%) showed increases greater than 30%.

Metabolic Processing

Significant increases in the downstream metabolites MeNAM and 2PY were consistent with increased NAD-related metabolic processing.

Short-Term Tolerability

LathMized® NAD+ was generally well tolerated during the five-day study. One mild adverse event involving nausea was reported in the treatment group, and no serious adverse events were observed.

Study note: These results provide evidence of a substantial response in the whole-blood intracellular NAD measurement, which predominantly reflects red blood cells. The study did not directly establish equivalent increases in muscle, brain, liver, or other tissues. Additional studies are needed to evaluate optimal dosing, longer-term safety, tissue-specific effects, and whether increased intracellular NAD translates into measurable functional health benefits.
The Molecule

What is NAD+ and why does it matter?

Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme involved in hundreds of enzymatic reactions throughout the body — cellular energy metabolism, mitochondrial processes, DNA maintenance, and cellular signaling. Research suggests that NAD+ concentrations may decline with aging in certain tissues, although the magnitude and timing vary by tissue and individual.

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Cellular Energy

Essential for reactions involved in ATP production — the energy currency of every cell.

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DNA Maintenance

Supports the function of NAD-dependent enzymes such as PARPs.

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Sirtuin Function

Serves as a required substrate for NAD-dependent sirtuin enzymes.

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Stress Responses

Participates in pathways involved in metabolic adaptation.

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Neuronal Metabolism

Contributes to the normal energy metabolism of nerve cells.

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Metabolic Regulation

Plays a central role in cellular redox reactions.

Why LathMized®

A Different Approach to Oral NAD+ Supplementation

💊

Formulated with NAD+

Contains NAD+ rather than relying exclusively on precursor ingredients such as NR or NMN.

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Clinically Studied

Demonstrated a significant increase in intracellular NAD measured in whole blood in a randomized, placebo-controlled human study.

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Published Research

Supported by peer-reviewed findings published in GeroScience.

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Needle-Free

An oral supplement approach that does not require intravenous administration.

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Proprietary Technology

Uses LathMized® processing technology developed to address NAD+ formulation challenges.

🎯

Science-First

Committed to advancing research into NAD+ metabolism, bioavailability, and cellular health.

The Products

The Protocol

A two-phase system: an intensive repletion program, followed by convenient daily maintenance.

Phase 1 — Repletion Program

LathMized® NAD+ Powder

$1,000 / 30-day supply

An oral NAD+ powder formulated with proprietary LathMized® technology. The proposed 30-day program provides a convenient daily supplementation format.

The published clinical trial evaluated a different dosing schedule over five days. The proposed commercial regimen has not been shown in that trial to reproduce the same NAD increase.
LathMized NAD+ Powder
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Phase 2 — Daily Maintenance

LathMized® NAD+ Sublingual Tablets

$200 / 30-day supply

A convenient sublingual tablet format containing LathMized® NAD+. Designed as an option for continued daily supplementation.

The ability of this 100 mg formulation to maintain the NAD increases observed in the published powder study has not yet been clinically established.
LathMized NAD+ Tablets
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Clinical Reference

Kornilov SA, et al. Oral LNAD+ rapidly elevates whole blood intracellular NAD and metabolic flux without elevating plasma NAD: evidence from a randomized controlled trial. GeroScience, 2026.

DOI: 10.1007/s11357-026-02399-1 · ClinicalTrials.gov: NCT07336836

Study note: The NAD measurement used an assay of total NAD (NAD+ and NADH). The results describe the whole-blood intracellular compartment and should not be interpreted as proof of increased NAD+ in every body tissue or of improvements in clinical health outcomes.